Вудалимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2329669-72-7

immunoglobulin half-IG G1-kappa/scFv-h-CH2-CH3, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte-associated protein 4, CD152)] and anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], monoclonal antibody, bispecific;
gamma1 heavy chain anti-CTLA4 (1-447) [VH (Homo sapiens IGHV3-48*03 (90.8%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 N114>D (209) R120>K (215) (119-216), hinge 1-15 (217-231), CH2 E1.4,L1.3>P (234), L1.2>V (235), G1.1>A (236), S29>K (267), Q84.2>E (295) (232-340), CH3 E12 (356), M14 (358), L24>D (368), K26>S (370), N44>D (384), Q97>E (418), N100>D (421), M107>L (428), N114>S (434) (341-445), CHS (446-447)) (119-447)], (221-215')-disulfide with kappa light chain anti-CTLA4, Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV3-20*01 (99.0%) -IGKJ1*01 (100%)) CDR-IMGT [7.3.9] (27-33.51-53.90-98) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109’-215’)];
IG scFv-h-CH2-CH3 single chain, anti-PDCD1 (1''-480'') [scFv V-kappa-VH anti-PDCD1 (1''-249'') [V-KAPPA (Homo sapiens IGKV3-15*01 (80.0%) -IGHJ4*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1''-107'') -20-mer tetrakis(glycyl-lysyl-prolyl-glycyl-seryl) linker (108''-127'') -VH (Mus musculus IGHV6-6*02 (87.0%) -(IGHD) -IGHJ1*03 (86.7%)/Homo sapiens IGHV3-15*07 (81.8%) -(IGHD) -IGHJ2*01 (93.3%)) CDR-IMGT [8.10.13] (153-160.178-187.226-238) (128''-249'')] -Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 (250''-480'') [hinge 1-15 C5>S (254) (250-264) -CH2 E1.4,L1.3>P (267), L1.2>V (268), G1.1>A (269), S29>K (300) (265-373),CH3 E12 (389), E13>Q (390), M14 (391), S20>K (397), M107>L (461), N114>S (467) (374-478), CHS (479-480)]];
dimer (227-260'':230-263'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-S cell line, glycoform alfa

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