Вусолимоген одерпарепвец

Rec. INN (наименование, зарегистрированное ВОЗ)

2305659-09-8

recombinant oncolytic herpes simplex virus 1 (HSV1) based on strain RH018A, with ICP47 (US12) and ICP34.5 (RL1) genes deleted, expressing the US11 gene under the control of the ICP47 promoter, and encoding two copies of an expression cassette inserted in opposite orientation at the ICP34.5 gene deletion sites, comprising codon-optimized human granulocytemacrophage colony-stimulating factor (hGM-CSF) and a fusogenic codon-optimized gibbon ape leukemia virus (GALV) glycoprotein lacking the R peptide (GALV-R). The hGM-CSF gene is under the control of a cytomegalovirus immediate-early (CMV IE) promoter/bovine growth hormone (BGH) polyadenylation sequence and the truncated GALV-R gene is under the control of a Rous sarcoma virus (RSV) promoter/simian virus 40 (SV40) polyadenylation sequence.

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