Ксирестомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2756879-35-1

immunoglobulin G1-scFv_L2 dimer, anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1) and anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily member 9, 4-1BB, T cell antigen ILA, CD137)], Homo sapiens monoclonal antibody, bispecific;
G1-scFv fused heavy chain Homo sapiens (1-713) [gamma1 heavy chain anti-CD274 Homo sapiens (1-448) [VH (Homo sapiens IGHV1-69*04 (96.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, G1v29 CH2 A84.4 (CH1 R120>K (218) (122-219), hinge 1-15 (220-234), CH2 N84.4>A (301) (235-344), CH3 E12 (360), M14 (362) (345-449)) (122-449)] -15-mer tris(tetraglycyl-seryl) linker (450-464) -scFv heavy-lambda anti-TNFRSF9 Homo sapiens (465-713) [VH (Homo sapiens IGHV3-23*04 (99.0%) -IGHD -IGHJ3*02 (100%), CDR-IMGT [8.8.13] (490-497.515-522.561-573)) (465-587) -15-mer tris(tetraglycyl-seryl) linker (588-602) -V-LAMBDA (Homo sapiens IGLV1-44*01 (95.9%) -IGLJ1*01 (91.7%) V124>L (709), CDR-IMGT [8.3.11] (628-635.653-655.692-702)) (603-713)]], (224-216')-disulfide with lambda2 light chain anti-CD274 Homo sapiens (1'-217') [V-LAMBDA (Homo sapiens IGLV2-14*03 (92.7%) -IGLJ2*01 (100%), CDR-IMGT [9.3.11] (26'-34'.52'-54'.91'-101')) (1'-111') -Homo sapiens IGLC2*01 (100%) (112'-217')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, non-glycosylated

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