Замубафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2937458-25-6

humanized immunoglobulin G1-kappa, anti-[human variable immunoglobulin light chain N-terminal cryptic neo-epitope] fused at the C-terminus of each light chain via a peptide linker to the pan-amyloid- reactive peptide p5R;
gamma 1 heavy chain (1-441) [VH (Homo sapiens IGHV4-4*08 -(IGHD) -IGHJ4*01, CDR-Kabat [5.16.3] (31-35.50-65.98-100)) (1-111) -Homo sapiens IGHG1*01 (CH1 (112-209), hinge (210-224), CH2 (225-334), CH3 (335-439), CHS (440-441)) (112-441)], (214-219')-disulfide with kappa light chain (1'-219') [V- KAPPA (Homo sapiens IGKV2-30*01 -IGKJ2*01, CDR-Kabat [16.7.9] (24'-39'.55'-61'.94'-102')) (1'-112') -Homo sapiens IGKC*01 (113'-219')], fused via peptide linker ²²⁰'VSPSV²²⁴' to the pan-amyloid-reactive peptide p5R (225'-250'), dimer (220-220'':223-223'')- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

Поделиться этой страницей