Зансецимаб
ZansecimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB16389
CAS
2415205-37-5
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens ANGPT2 (angiopoietin 2)], humanized monoclonal antibody;
gamma4 heavy chain humanized (1-447) [VH (Homo sapiens IGHV1-18*01 (86.7%) -(IGHD) -IGHJ4*01 (93.3%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -Homo sapiens IGHG4*01, G4v5 h P10, G4v4 CH2 A1.3, A1.2 (CH1 (122-219), hinge 1-12 S10>P (229) (220-231), CH2 F1.3>A (235), L1.2>A (236) (232-341), CH3 (342-446), CHS K>del (447)) (122-447)], (135-214')-disulfide with kappa light chain humanized (1’-214’) [V-KAPPA (Homo sapiens IGKV1-12*01 (83.2%) -IGKJ4*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227":230-230")-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-GSKO, glycoform alfa
gamma4 heavy chain humanized (1-447) [VH (Homo sapiens IGHV1-18*01 (86.7%) -(IGHD) -IGHJ4*01 (93.3%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -Homo sapiens IGHG4*01, G4v5 h P10, G4v4 CH2 A1.3, A1.2 (CH1 (122-219), hinge 1-12 S10>P (229) (220-231), CH2 F1.3>A (235), L1.2>A (236) (232-341), CH3 (342-446), CHS K>del (447)) (122-447)], (135-214')-disulfide with kappa light chain humanized (1’-214’) [V-KAPPA (Homo sapiens IGKV1-12*01 (83.2%) -IGKJ4*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227":230-230")-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-GSKO, glycoform alfa
Структура
Иностранные названия
- Zansecimabum (латинское)
- Zansecimab (английское)
- Zansecimab (немецкое)
- Zansécimab (французское)
- Zansecimab (испанское)
Подробнее по теме
Узнайте дополнительные сведения о действующем веществе Зансецимаб: