Запомеран

Rec. INN (наименование, зарегистрированное ВОЗ)

2727965-96-8

self-replicating messenger RNA (mRNA), 5'-capped, encoding codon-optimised Venezuelan equine encephalitis virus (VEEV) RNA-dependent RNA polymerase (VEEV proteins nsP1, nsP2, nsP3 and nsP4) and a full-length codon-optimised pre-fusion stabilised conformation variant (K986P and V987P) of the SARS- CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein (derived from GenBank ID YP_009724390) containing furin cleavage-inactivating mutations (R682G, R683S, R685S) plus an additional mutation (D614G), flanked by 5' and 3' untranslated regions and a 3' polyadenylation (polyA) tail; generation of the capped S mRNA is under control of a VEEV subgenomic promoter.

Поделиться этой страницей