Зелецимент басиварсен

Rec. INN (наименование, зарегистрированное ВОЗ)

2767191-74-0

immunoglobulin Fab G1-kappa (VH-CH1_L-kappa), anti-[Homo sapiens TFRC (transferrin receptor, TfR1, TFR1, CD71)], monoclonal antibody; conjugated at lysine residues with basivarsen;
Fab-G1 VH-CH1 heavy chain (1-227) [VH Musmus/Homsap (Mus muculus IGHV3-6*01 (84.5%) -(IGHD) -IGHJ2*01 (85.7%) L124>V (115)/Homo sapiens IGHV4-30-4*01 (82.8%) -(IGHD) -IGHJ4*01 (85.7%) L123>T (114), CDR-IMGT [9.7.12] (26-34.52-58.97-108)) (1-119) -Homo sapiens IGHG1*01 (100%) CH1-h (100%), G1m17 CH1 K120 (CH1 K120 (216) (120-217), hinge 1-10 (218-227)) (120-227)], (222-214')-disulfide with L-kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (85.3%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.51-53.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')], produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, non-glycosylated; substituted at N⁶ of 1 to 3 l-lysine residues with 1-{(5aRS,6SR,6aSR)-1-[(6S,9S)-1-amino-6-{[4-({[(6-{[all-P-ambo-2'-O,4'-C-methylene-P-thioadenylyl-(5'→3')-5-methyl-2'-O,4'-C-methylene-P-thiocytidylyl-(5'→3')-2'-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(5'→3')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(5'→3')-2'-deoxy-P-thioadenylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thioadenylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thioguanylyl-(5'→3')-5-methyl-2'-O-(2-methoxyethyl)-P-thiocytidylyl-(5'→3')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(5'→3')-2'-O,4'-C-methylene-P-thioadenylyl-(5'→3')-5-methyl-2'-O,4'-C-methylene-5'-cytidylyl]oxy}hexyl)carbamoyl]oxy}methyl)pheny]carbamoyl}-1,8,11-trioxo-9-(propan-2-yl)-14,17,20-trioxa-2,7,10-triazadocosan-22-yl]-1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d][1,2,3]triazol-6-yl}-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oyl (basivarsen) groups
immunoglobulin Fab G1-kappa (VH-CH1_L-kappa), anti-[Homo sapiens TFRC (transferrin receptor, TfR1, TFR1, CD71)], monoclonal antibody; conjugated at lysine residues with basivarsen;
Fab-G1 VH-CH1 heavy chain (1-227) [VH Musmus/Homsap (Mus muculus IGHV3-6*01 (84.5%) -(IGHD) -IGHJ2*01 (85.7%) L124>V (115)/Homo sapiens IGHV4-30-4*01 (82.8%) -(IGHD) -IGHJ4*01 (85.7%) L123>T (114), CDR-IMGT [9.7.12] (26-34.52-58.97-108)) (1-119) -Homo sapiens IGHG1*01 (100%) CH1-h (100%), G1m17 CH1 K120 (CH1 K120 (216) (120-217), hinge 1-10 (218-227)) (120-227)], (222-214')-disulfide with L-kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (85.3%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.51-53.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')], produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, non-glycosylated; substituted at N⁶ of 1 to 3 l-lysine residues with 1-{(5aRS,6SR,6aSR)-1-[(6S,9S)-1-amino-6-{[4-({[(6-{[all-P-ambo-2'-O,4'-C-methylene-P-thioadenylyl-(5'→3')-5-methyl-2'-O,4'-C-methylene-P-thiocytidylyl-(5'→3')-2'-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(5'→3')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(5'→3')-2'-deoxy-P-thioadenylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thioadenylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thiocytidylyl-(5'→3')-2'-deoxy-P-thioguanylyl-(5'→3')-5-methyl-2'-O-(2-methoxyethyl)-P-thiocytidylyl-(5'→3')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(5'→3')-2'-O,4'-C-methylene-P-thioadenylyl-(5'→3')-5-methyl-2'-O,4'-C-methylene-5'-cytidylyl]oxy}hexyl)carbamoyl]oxy}methyl)pheny]carbamoyl}-1,8,11-trioxo-9-(propan-2-yl)-14,17,20-trioxa-2,7,10-triazadocosan-22-yl]-1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d][1,2,3]triazol-6-yl}-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oyl (basivarsen) groups

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