Зелецимент ростудирсен

Rec. INN (наименование, зарегистрированное ВОЗ)

2725863-42-1

immunoglobulin Fab-G1kappa (VH-CH1_L-kappa), anti-[Homo sapiens TFRC (transferrin receptor, TfR1, TFR1, CD71)], monoclonal antibody, conjugated at lysine residues with rostudirsen;
Fab-G1 VH-CH1 chain (1-227) [VH Musmus/Homsap (Mus muculus IGHV3-6*01 (84.5%) -(IGHD) -IGHJ2*01 (85.7%) L124>V (115)/Homo sapiens IGHV4-30-4*01 (82.8%) -(IGHD) -IGHJ4*01 (85.7%) L123>T (114), CDR-IMGT [9.7.12] (26-34.52-58.97-108)) (1-119) -Homo sapiens IGHG1*01 CH1-h (100%), G1m17 CH1 K120 (CH1 K120 (216) (120-217), hinge 1-10 (218-227)) (120-227)], (222-214')-disulfide with L-kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (85.3%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.51-53.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')], produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, non-glycosylated; substituted at N⁶ of 1 to 3 l-lysine residues with 1-{(5aRS,6SR,6aSR)-1-[(6S,9S)-6-[(4-{[({6-[(4-{4-[{all-P-ambo-2'¹-N-acetyl[2',3'-azanediyl-P,2',3'-trideoxy-P-(dimethylamino)-2',3'-seco](5'→2'-N)(GATCTTTACG GTAGAAGGAA CTACAACCTC-5'-O)}(dimethylamino)phosphoryl]piperazin-1-yl}-6-[(2-amino-2-oxoethyl)(methyl)amino]-1,3,5-triazin-2-yl)oxy]hexyl}carbamoyl)oxy]methyl}phenyl)carbamoyl]-1-amino-1,8,11-trioxo-9-(propan-2-yl)-14,17,20-trioxa-2,7,10-triazadocosan-22-yl]-1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d][1,2,3]triazol-6-yl}-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oyl (rostudirsen) groups

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