Зелувалимаб
ZeluvalimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2315361-37-4
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], monoclonal antibody;
gamma1 heavy chain (1-450) [VH (Homo sapiens IGHV3-23*03 (92.8%) -(IGHD) -IGHJ3*01 (92.3%)) CDR-IMGT [8.8.13] (26-33.50-58.97-109) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 R83>C (295), N84.4>G (300), V85>C (305) (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450) (121-450)], (223-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (96.8%) -IGKJ4*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, non-glycosylated
gamma1 heavy chain (1-450) [VH (Homo sapiens IGHV3-23*03 (92.8%) -(IGHD) -IGHJ3*01 (92.3%)) CDR-IMGT [8.8.13] (26-33.50-58.97-109) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 R83>C (295), N84.4>G (300), V85>C (305) (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450) (121-450)], (223-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (96.8%) -IGKJ4*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, non-glycosylated
Структура
Иностранные названия
- Zeluvalimabum (латинское)
- Zeluvalimab (английское)
- Zeluvalimab (немецкое)
- Zéluvalimab (французское)
- Zeluvalimab (испанское)
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