Земоцимиг

Prop. INN (наименование, предложенное ВОЗ)

immunoglobulin (H-gamma4_L-kappa)_( H-gamma4_L-lambda2), anti-[Homo sapiens F9a (coagulation factor F9, coagulation factor IX, hemophilia B) activated ] and anti-[Homo sapiens F10 (coagulation factor 10, coagulation factor X)], humanized and Homo sapiens monoclonal antibody, bispecific, bivalent;
H-gamma4 heavy chain anti-F9a humanized (1-447) [VH (Homo sapiens IGHV3-23*04 (87.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, 12-G4v5 h P10, 17-G4v57-1 CH1 K84.2, 18-G4v11 CH1 Q100, CH2 Y84.3, 14-G4v12-1 CH3 K12, 12-G4v6 CH3 K88, 9-G4v78 L107, A114, 10-G4v89 CH3 R118, E120 (CH1 Q84.2>K (180), K100>Q (201) (123-220), hinge 1-12 S10>P (230) (221-232), CH2 F84.3>Y (298), L92 (311) (233-342), CH3 E12>K (358), R88>K (411), M107>L (430), N114>A (436), Q118>R (440), S120>E (442) (343-447)) (123-447)], (136-214')-disulfide with L-kappa light chain anti-F9a Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3D-11*02 (84.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (98.1%) Km3 A45.1, V101 KCv57-1 E20, E90 (C-KAPPA S20>E (131'), A45.1 (153'), T90>E (180), V101 (191')) (108'-214')];
 H-gamma4 heavy chain anti-F10 humanized (1''-444'') [VH (Homo sapiens IGHV1-2*06 (74.5%) -(IGHD) -IGHJ4*01 (80.0%) Q120>E (111''), CDR-IMGT [8.8.12] (26''-33''.51''-58''.97''-108'')) (1''-119'') -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, 12-G4v5 h P10, 17-G4v57-2 CH1 E26, K84.2, 18-G4v11 CH1 Q100, CH2 Y84.3, 12-G4v6 CH3 K88, 9-G4v78 L107, A114, 10-G4v89 CH3 R118, E120, 14-G4v13  CH3 E119 (CH1 K26>E (149''), Q84.2>E (177''), K100>Q (198'') (120''-217''), hinge 1-12 S10>P (227'') (218''-229''), CH2 F84.3>Y (295''), L92 (308'') (230''-339''), CH3 R88>K (408''), M107>L (427''), N114>A (433''), Q118>R (437''), K119>E (438''), S120>E (439'') (340''-444'')) (120''-444'')], (133''-212''')-disulfide with L-lambda2 light chain anti-F10 Homo sapiens (1''-213''') [V-LAMBDA (Homo sapiens IGLV3-9*01 (78.7%) -IGLJ2*01 (81.8%) L124>V (104'''), L127>V (107'''), CDR-IMGT [6.3.10] (26'''-31'''.49'''-51'''.88'''-97''')) (1'''-107''') -Homo sapiens IGLC2*01 (98.1%) LC2v57-2 K20, K90 (C-LAMBDA2 T20>K (132'''), S90>K (180''') (108'''-213''')]; dimer (228-225'': 231-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DXB11, glycoform alfa

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