Зерипатамиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2607644-43-7

immunoglobulin G1-kappa/lambda, anti-[Homo sapiens CD47 (integrin-associated protein, IAP, MER6, OA3) and anti-[Homo sapiens CD19 (B lymphocyte surface antigen B4, Leu-12)], Homo sapiens monoclonal antibody, bispecific;
gamma1 heavy chain Homo sapiens (1-445) [VH (Homo sapiens IGHV3-23*01 (100%) -(IGHD) -IGHJ4*01 (100%)), CDR-IMGT [8.8.9] (26-33.51-58.97-105) (1-116) -Homo sapiens IGHG1*03, G1m3, nG1m1 (CH1 R120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 E12 (355), M14 (357) (340-444), CHS K2>del (445)) (117-445)], (219-215')-disulfide with kappa light chain anti-CD47 Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV1-39*01 (100%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.10] (27-32.50-52.89-98) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')];
gamma1 heavy chain Homo sapiens (1''-445'') [VH (Homo sapiens IGHV3-23*01 (100%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.9] (26-33.51-58.97-105) (1''-116'') -Homo sapiens IGHG1*03, G1m3, nG1m1 (CH1 R120 (213) (117''-214''), hinge 1-15 (215''-229''), CH2 (230''-339''), CH3 E12 (355), M14 (357) (340''-444''), CHS K2>del (445)) (117''-445'')], (219''-217''')-disulfide with lambda light chain anti-CD19 Homo sapiens (1'''-218''') [V-LAMBDA (Homo sapiens IGLV6-57*01 (91.8%) -IGLJ3*02 (100%)) CDR-IMGT [8.3.11] (26-33.51-53.92-102) (1'''-112''') -Homo sapiens IGLC2*01 (100%) (113'''-218''')];
dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

Поделиться этой страницей