Зифкасиран

C₇₃₇H₉₇₂F₂₀N₂₁₁O₃₄₉P₄₃S₈

• Химическое название: all-P-ambo-(2R,3S)-2-[({[(6-{[(3RS)-1-(6-{[(2S)-2-carboxy-2-(17-carboxyheptadecanamido)ethyl]amino}-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}hexyl)oxy]hydroxyphosphoryl}oxy) methyl]oxolan-3-yl hydrogen 5'-O-{27-[(6S)-6-(carboxymethyl)-7³-fluoro-5²-oxo-1^5,6,7,8-tetrahydro-8,11,14,17-tetraoxa-1(2)-[1,8]naphthyridina-20(1)-[1,2,3]triazola-5(1,3)-imidazolidina-7(1,4)-benzenaicosaphan-20⁴-yl]-16,16-bis(3-{[2-(2-{[(6S)-6-(carboxymethyl)-7³-fluoro-5²-oxo-1^5,6,7,8-tetrahydro-8,11,14,17-tetraoxa-1(2)-[1,8]naphthyridina-20(1)-[1,2,3]triazola-5(1,3)-imidazolidina-7(1,4)-benzenaicosaphan-20⁴-yl]methoxy}ethoxy)ethyl]amino}-3-oxopropyl)-1,10,14,19-tetraoxo-1-sulfanyl-2,23,26-trioxa-9,15,20-triaza-1λ⁵-phosphaheptacosan-1-yl}-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-{[(6S)-6-(carboxymethyl)-7³-fluoro-5²-oxo-1^5,6,7,8-tetrahydro-8,11,14,17-tetraoxa-1(2)-[1,8]naphthyridina-20(1)-[1,2,3]triazola-5(1,3)-imidazolidina-7(1,4)-benzenaicosaphan-20⁴-yl]methyl}uridylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-{[(6S)-6-(carboxymethyl)-7³-fluoro-5²-oxo-1^5,6,7,8-tetrahydro-8,11,14,17-tetraoxa-1(2)-[1,8]naphthyridina-20(1)-[1,2,3]triazola-5(1,3)-imidazolidina-7(1,4)-benzenaicosaphan-20⁴-yl]methyl}adenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-{[(6S)-6-(carboxymethyl)-7³-fluoro-5²-oxo-1^5,6,7,8-tetrahydro-8,11,14,17-tetraoxa-1(2)-[1,8]naphthyridina-20(1)-[1,2,3]triazola-5(1,3)-imidazolidina-7(1,4)-benzenaicosaphan-20⁴-yl]methyl}guanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-{[(6S)-6-(carboxymethyl)-7³-fluoro-5²-oxo-1^5,6,7,8-tetrahydro-8,11,14,17-tetraoxa-1(2)-[1,8]naphthyridina-20(1)-[1,2,3]triazola-5(1,3)-imidazolidina-7(1,4)-benzenaicosaphan-20⁴-yl]methyl}-P-thioadenylyl-(3'→5')-2'-O-methyl-3'-adenylate, duplex with all-P-ambo-2'-O-methyl-P-thiouridylyl-(3'→5')-2'-deoxy-2'-fluoro-P-thiouridylyl-(3'→5')-2'-O-methyl-P-thiouridylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoro-P-thiouridylyl-(3'→5')-2'-O-methylguanosine
• CAS: 2437257-11-7
• Структура

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