Зифибанцимиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2517939-46-5

immunoglobulin Fab G1-kappa, anti-[Homo sapiens ANGPT2 (angiopoietin 2, Ang2)] and anti-[Homo sapiens VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF), monoclonal antibody, bispecific, biparatope monovalent;
VH-(CH1-hinge) gamma1 heavy chain (1-223) [VH (Homo sapiens IGHV3-31*07 (74.0%) -(IGHD) -IGHJ4*01 (86.7%), CDR-IMGT [7.8.9] (26-32.50-57.96-104)) (1-115) -CH1-hinge (Homo sapiens IGHG1*01 (100%), G1m17 (CH1 K120 (212) (116-213), hinge 1-10 (214-223)) (116-223)], (218-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-5*01 (72.2%) -IGKJ4*01 (90.9%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; bispecific, biparatope monovalent: anti-ANG2 paratope (VH CDR1 and CDR3, V-KAPPA CDR2) and anti-VEGFA paratope (V-KAPPA CDR1 and CDR3, VH CDR2), produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, non-glycosylated

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