Зиловертамаб ветодин

Rec. INN (наименование, зарегистрированное ВОЗ)

2376463-48-6

immunoglobulin G1-kappa, anti-[Homo sapiens ROR1 (receptor tyrosine kinase like orphan receptor 1, NTRKR1)], humanized monoclonal antibody conjugated to auristatin E;
gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV2-70*19 (65.0%) -(IGHD) -IGHJ4*01 (93.3%) Q120>H (108)) CDR-IMGT [8.7.10] (26-33.51-57.96-105) (1-116) -Homo sapiens IGHG1*01 (100%) G1m17,1 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (117-446)], (219-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV3D-11*02 (67.8%) -IGKJ4*01 (90.9%) G120>E (100)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; conjugated on an average of 4.0 ± 0.5 cysteinyl to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker

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