Цирконий (89Zr) крефмирлимаб бердоксам
Zirconium (89Zr) crefmirlimab berdoxamМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2377668-38-5
Химическое название
immunoglobulin scFv-kappa-heavy-G1h-CH3-CHS dimer, anti-[Homo sapiens CD8A (CD8a molecule, CD8)], monoclonal antibody;
scFv-kappa-heavy-G1-h-linker-CH3-CHS chain (1-376) [V-KAPPA (Homo sapiens IGKV1-27*01 (87.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1-107) -18-mer glycyl-seryl-threonyl-tris(seryl-triglycyl)-glycyl-diseryl linker (108-125) -VH Musmus/Homsap (Mus musculus IGHV14-3*02 (73.5%) -(IGHD) -IGHJ3*01 (84.6%)/Homo sapiens IGHV3-66*01 (71.4%) -(IGHD) -IGHJ1*01 (92.3%), CDR-IMGT [8.8.11] (151-158.176-183.222-232)) (126-243) -Homo sapiens IGHG1*03 hinge 1-17 (244-260), 10-mer triglycyl-diseryl-triglycyl-seryl-glycyl linker (261-270), Homo sapiens IGHG1*03 nG1m1 CH3-CHS (CH3 E12 (286), M14 (288) (271-375), CHS K2>del (376)) (271-376)]; dimer (254-254'':257-257'':260-260'')-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, non-glycosylated, conjugated at N6 of lysine residues with an average of 0.8-2.5 [4‑(8,19,30-trihydroxy-9,12,20,23,31-pentaoxo-2,8,13,19,24,30-hexaazadotriacontane-1-thioyl)phenyl]carbamothioyl (berdoxam) groups and converted to (89Zr) zirconium (4+) chelate complex salts
scFv-kappa-heavy-G1-h-linker-CH3-CHS chain (1-376) [V-KAPPA (Homo sapiens IGKV1-27*01 (87.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1-107) -18-mer glycyl-seryl-threonyl-tris(seryl-triglycyl)-glycyl-diseryl linker (108-125) -VH Musmus/Homsap (Mus musculus IGHV14-3*02 (73.5%) -(IGHD) -IGHJ3*01 (84.6%)/Homo sapiens IGHV3-66*01 (71.4%) -(IGHD) -IGHJ1*01 (92.3%), CDR-IMGT [8.8.11] (151-158.176-183.222-232)) (126-243) -Homo sapiens IGHG1*03 hinge 1-17 (244-260), 10-mer triglycyl-diseryl-triglycyl-seryl-glycyl linker (261-270), Homo sapiens IGHG1*03 nG1m1 CH3-CHS (CH3 E12 (286), M14 (288) (271-375), CHS K2>del (376)) (271-376)]; dimer (254-254'':257-257'':260-260'')-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, non-glycosylated, conjugated at N6 of lysine residues with an average of 0.8-2.5 [4‑(8,19,30-trihydroxy-9,12,20,23,31-pentaoxo-2,8,13,19,24,30-hexaazadotriacontane-1-thioyl)phenyl]carbamothioyl (berdoxam) groups and converted to (89Zr) zirconium (4+) chelate complex salts
Структура
Иностранные названия
- Zirconium (89Zr) crefmirlimabum berdoxamum (латинское)
- Zirconium (89Zr) crefmirlimab berdoxam (английское)
- Zirconium (89Zr) crefmirlimab berdoxam (немецкое)
- Zirconium (89Zr) crefmirlimab berdoxam (французское)
- Zirconium (89Zr) crefmirlimab berdoxam (испанское)
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