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Rec. INN (наименование, зарегистрированное ВОЗ)

2640279-10-1

immunoglobulin (H-gamma1_L-kappa)_(H-gamma1_L-lambda2), anti-[Homo sapiens VTCN1 (V-set domain containing T cell activation inhibitor 1, B7 family member H4, B7H4, B7-H4) and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], bispecific;
H-gamma1 heavy chain anti-VTCN1 (1-446) [VH (Homo sapiens IGHV4-34*01 (95.9%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.7.11] (26-33.51-57.96-106)) (1-117) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v41 CH2 F1.3, E1.2, G1v66 CH2 A27, G1v82-2 CH3 R88 (CH1 R120 (214) (118-215), hinge 1-15 (216-230), CH2 L1.3>F (234), L1.2>E (235), D27>A (265) (231-340), CH3 E12 (356), M14 (358), K88>R (409) (341-445), CHS K2>del (446)) (118-446)], (220-214')-disulfide with L-kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-17*01 (98.9%) -IGKJ1*01 (90.9%) K123>T (103'), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')];
H-gamma1 heavy chain anti-CD3E (1''-454'') [VH Musmus/Homsap (Mus musculus IGHV10-1*02 (93.9%) -(IGHD) -IGHJ3*01 (93.3%) A128>S (125'')/Homo sapiens IGHV3-72*01 (81.0%) -(IGHD) -IGHJ6*01 (90.9%) T123>L (120''), CDR-IMGT [8.10.16] (26''-33''.51''-60''.99''-114'')) (1''-125'') -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v41 CH2 F1.3, E1.2, G1v66 CH2 A27, G1v82-1 CH3 L85.1 (CH1 R120 (222'') (126''-223''), hinge 1-15 (224''-238''), CH2 L1.3>F (242''), L1.2>E (243''), D27>A (273'') (239''-348''), CH3 E12 (364''), M14 (366''), F85.1>L (413'') (349''-453''), CHS K2>del (454'')) (126''-454'')], (228''-214''')-disulfide with L-lambda2 light chain (1'''-215''') [V-LAMBDA Musmus/Homsap (Mus musculus IGLV1*01 (83.3%) -IGLJ1*01 (100%)/Homo sapiens IGLV8-61*01 (70.8%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (26'''-34'''.52'''-54'''.91''''-99'''') (1'''-109''') -Homo sapiens IGLC2*01 (100%) (110'''-215''')]; dimer (226-234'':229-237'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa

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