Зуниберген рокпарвовек

Prop. INN (наименование, предложенное ВОЗ)

2856381-73-0

recombinant non-replicating adeno-associated virus (AAV) vector with a retina-specific capsid variant, encoding a microRNA (miRNA) targeting expression of vascular endothelial growth factor C (VEGF-C) and a codon-optimised fusion protein that consists of VEGF- binding regions derived from the extracellular domains of human VEGF receptors 1 and 2 fused to the Fc portion of human immunoglobulin G1 (the mature expressed protein is equivalent to aflibercept), under control of a synthetic CAG promoter and the simian virus 40 polyadenylation sequence, flanked by AAV2 inverted terminal repeats. The VEGF-C targeting miRNA sequence is located within the chicken beta-actin intron of the CAG promoter

Поделиться этой страницей