Амивантамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

DB16695

Противоопухолевые средства — моноклональные антитела

N (не классифицировано FDA)

2171511-58-1

immunoglobulin G1-kappa, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)] and anti-[Homo sapiens MET (met proto-oncogene, hepatocyte growth factor (HGF) receptor, HGFR, scatter factor (SF) receptor, HGF/SF receptor, receptor tyrosine-protein kinase c-met, papillary renal cell carcinoma 2, RCCP2)], Homo sapiens monoclonal antibody, bispecific;
gamma1 heavy chain Homo sapiens anti-EGFR (1-455) [VH (Homo sapiens IGHV3-33*01 (95.9%) -(IGHD) -IGHJ4*01 (100%)) [8.8.18] (1-125) -Homo sapiens IGHG1*03 G1m3, nG1m1 (CH1 R120 (222) (126-223), hinge 1-15 (224-238), CH2 (239-348), CH3 E12 (364), M14 (366), F85.1>L (413) (349- 453), CHS (454-455)) (126-455)], (228-214')-disulfide with kappa light chain Homo sapiens anti-EGFR (1'-214') [V-KAPPA (Homo sapiens IGKV1-13*02 (96.8%) -IGKJ4*01 (100%)) [6.3.9] (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-213')]; gamma1 heavy chain Homo sapiens anti-MET (1''-449'') [VH (Homo sapiens IGHV1-18*01 (95.9%) -(IGHD) -IGHJ4*01 (100%)) [8.8.12] (1''-119'') -Homo sapiens IGHG1*03 G1m3, nG1m1 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360), K88>R (411) (343- 447), CHS (448-449)) (119''-449'')], (222''-214''')-disulfide with kappa light chain Homo sapiens anti-MET (1'''-214''') [V-KAPPA (Homo sapiens IGKV1- 12*01 (95.8%) -IGKJ5*01 (100%)) [6.3.9] (1'''-107''') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'''-214''')];
dimer (234-228'':237-231'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO) cells, glycoform alfa

C₆₄₇₂H₁₀₀₁₄N₁₇₃₀O₂₀₂₃S₄₆

145902,15 г/моль

Поделиться этой страницей