Эмицизумаб

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB13923

Противоопухолевые средства — моноклональные антитела

N (не классифицировано FDA)

1610943-06-0

immunoglobulin G4-kappa, bispecific, anti-[Homo sapiens F9a (activated coagulation factor F9, activated coagulation factor IX) and anti-[Homo sapiens F10 (coagulation factor 10, coagulation factor X)], humanized monoclonal antibody;
gamma4 heavy chain (1-448) [humanized VH (Homo sapiens IGHV3-23*04 (87.80%) -(IGHD)-IGHJ4*01 (1- 123)), IGHG4*01 (CH1 K100>Q (202) (124-221), hinge S10>P (231) (222-233), CH2 F84.3>Y (299) (234-343), CH3 E12>K (359), R88>K (412), H115>R (438), L125>P (448) (344-448), CHS>del) (124-448)], (137-214')-disulfide with kappa light chain (1’-214’) [humanized V-KAPPA (Homo sapiens IGKV1-39*01 (80.00%) -IGKJ4*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 (108'-214')]; gamma4 heavy chain (1-444) [VH (Homo sapiens IGHV1- 2*02 (75.50%) -(IGHD)-IGHJ6*03 Q120>E (111''), T123>L (114'') (1''-119'')), IGHG4*01 (CH1 A100>Q (198'') (120''- 217''), hinge S10>P (227'') (218''-229''), CH2 F84.3>Y (295''), (230''-339''), CH3 R88>K (408), K119>E (438), L125>P (444) (340''-444''), CHS>del) (120''-444'')], (133''- 214''')-disulfide with kappa light chain (1'''-214''') [humanized V-KAPPA (Homo sapiens IGKV1-39*01 (80.00%) -IGKJ4*01) [6.3.9] (1'''-107''') -Homo sapiens IGKC*01, Km3 (108'''-214''')]; dimer (229-225":232-228")- bisdisulfide

C₆₄₃₄H₉₉₄₀N₁₇₂₄O₂₀₄₇S₄₅

145639,02 г/моль

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