Гофликицепт

Rec. INN (наименование, зарегистрированное ВОЗ)

DB16396

Иммунодепрессанты

N (не классифицировано FDA)

2416984-26-2

human interleukin-1 receptor accessory protein fragment (21-358, 1-338 in the current sequence) fused via peptidyl linker ³³⁹GSGGG³⁴³ to a human immunoglobulin G1 Fc fragment (344-570, C-terminal Lys clipped) variant (S>C⁴⁷⁷, T>W⁴⁸⁹, K>A⁵³²), covalent dimer with human interleukin-1 receptor type 1 fragment (21-333, 1-313 in the current sequence) fused via peptidyl linker ³¹⁴GSGG³¹⁸ to a human immunoglobulin G1 Fc fragment (319-545, C-terminal Lys clipped) variant (Y>C⁴⁴⁷, T>S⁴⁶⁴, L>A⁴⁶⁶, F>K⁵⁰³, Y>V⁵⁰⁵), glycosylated, produced in Chinese hamster ovary (CHO) cells;
fusion protein comprising the (1-338)-fragment of the human interleukin 1 receptor accessory protein (IL1RAP, IL-1RAcP, interleukin-1 receptor 3, IL1R3), a GSGGG linker (339-343), and the (S>C⁴⁷⁷, T>W⁴⁸⁹, K>A⁵³²) variant of the C-terminal 227-peptide (Fc fragment) of human immunoglobulin G1 (344-570), (349- 324':352-327':477-447')-trisdisulfide with a fusion protein comprising the (21-333)-fragment of the precursor of human interleukin 1 receptor type 1 (IL1R1, IL1Rα, IL1R type I, p80, CD121a) (1-313), a GSGGG linker (314-318), and the (Y>C⁴⁴⁷, T>S⁴⁶⁴, L>A⁴⁶⁶, F>K⁵⁰³, Y>V⁵⁰⁵) variant of the C-terminal 227-peptide (Fc fragment) of human immunoglobulin G1 (319-545), produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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