Идекабтаген виклейцел

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

human culture expanded genetically modified autologous T cells for cell-based gene therapy. Cells are derived from isolated blood of the patient and are transduced with nonreplicative self-inactivating (SIN) human immunodeficiency virus type 1 (HIV-1) based lentiviral vector (LVV) pseudotyped with the vesicular stomatitis virus glycoprotein G (VSV-G) envelope protein, and encoding the C11D5.3 antiTNF receptor superfamily member 17 (TNFRSF17, BCMA) single chain variable fragment (scFv) CD8/4-1BB/CD3zeta chimeric antigen receptor (CAR) under the transcriptional control of the myeloproliferative sarcoma virus enhancer, negative control region deleted, dl587rev primer-binding site substituted (MND) promoter. Cells exhibit anti-tumoral activity in patients with multiple myeloma.

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