Мосунетузумаб

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB15434

Противоопухолевые средства — моноклональные антитела

N (не классифицировано FDA)

1905409-39-3

immunoglobulin G1-kappa, anti-[Homo sapiens CD3E (CD3 epsilon) and Homo sapiens MS4A1 (membrane-spanning 4-domains subfamily A member 1, CD20)], humanized monoclonal antibody, bispecific;
gamma1 heavy chain anti-CD3E (1-449) [humanized VH (Homo sapiens IGHV1-3*01 (82.70%) -(IGHD) -IGHJ4*01) [8.8.12] (1-119) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (216) (120-217), hinge (218-232), CH2 N84.4>G (299) (233-342), CH3 E12 (358), M14 (360), T22>S (368) / L24>A (370) / Y86>V (409) (hole) (343-447), CHS (448-449)) (120-449)], (222-219')-disulfide with kappa light chain anti-CD3E (1’-219’) [humanized V-KAPPA (Homo sapiens IGKV4-1*01 (91.80%) -IGKJ1*01) [12.3.8] (1'-112') -Homo sapiens IGKC*01, Km3 A45.1 (158), V101 (196) (113'-219')];
gamma1 heavy chain anti-MS4A1 (1-452) [humanized VH (Homo sapiens IGHV3-23*04 (81.60%) -(IGHD)-IGHJ4*01) [8.8.15] (1-122) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (219) (123-220), hinge (221-235), CH2 N84.4>G (302) (236-345), CH3 E12 (361), M14 (363), T22>W (371) (knob) (346-450), CHS (451-452)) (123-452)], (225-213')-disulfide with kappa light chain anti-MS4A1 (1’-213’) [humanized V-KAPPA (Homo sapiens IGKV1-39*01 (86.50%) -IGKJ1*01) [5.3.9] (1'-106') -Homo sapiens IGKC*01, Km3 A45.1 (152), V101 (190) (107'-213')];
dimer (228-231":231-234")-bisdisulfide

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