Палопегтерипаратид

Rec. INN (наименование, зарегистрированное ВОЗ)

N (не классифицировано FDA)

2222514-07-8

human parathyroid hormone (PTH) synthetic peptide fragment (1-34), conjugated at the N-terminal amino group via a cleavable linker to O-methylpolyethylene glycol (2 x 20 kDa mPEG);
2-methylalanyl-(1-34)-peptide of parathyroid hormone (Homo sapiens parathyrin, parathormone, PTH) conjugated with O-methylpolyethylene glycol via a cleavable linker at the N-terminal amino group: N-({2-[(6-{[(3RS)-1-{3-[(3-{(2Ξ)-2,3-bis[αmethylpoly(oxyethylene)-ω-oxy]propoxy}propyl)amino]-3-oxopropyl}-2,5-dioxopyrrolidin-3-yl]sulfanyl}hexyl)amino]ethyl}carbamoyl)-2-methylalanyl-L-seryl-L-valyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-Llysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-αaspartyl-L-valyl-L-histidyl-L-asparaginyl-L-phenylalanine

C₂₀₉H₃₄₀N₆₀O₅₉S₃(C₂H₄O)_2n, n ≈ 450-500

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