Пенпулимаб
PenpulimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2350298-92-7
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], monoclonal antibody;
gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV3-23*04 (88.7%) -(IGHD) -IGHJ6*01 (90.9%)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*01 G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 L1.3>A (235), L1.2>A (236), G1>A (238) (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)], (221-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Mus musculus IGKV14-111*01 (86.3%) -IGKJ5*01 (100%) /Homo sapiens IGKV1-16*01 (80%) -IGKJ2*01 (81.8%) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV3-23*04 (88.7%) -(IGHD) -IGHJ6*01 (90.9%)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*01 G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 L1.3>A (235), L1.2>A (236), G1>A (238) (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)], (221-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Mus musculus IGKV14-111*01 (86.3%) -IGKJ5*01 (100%) /Homo sapiens IGKV1-16*01 (80%) -IGKJ2*01 (81.8%) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
Структура
Иностранные названия
- Penpulimabum (латинское)
- Penpulimab (английское)
- Penpulimab (немецкое)
- Penpulimab (французское)
- Penpulimab (испанское)
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