Тарлатамаб

Tarlatamab

МНН

Rec. INN (зарегистрированное ВОЗ)

CAS

2307488-83-9

Химическое название

immunoglobulin scFv-scFv-scFc, anti-[Homo sapiens DLL3 (delta-like ligand 3)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain (scFv)2-scFc, bispecific;
IG single chain scFv-scFv-scFc, anti-DLL3 and anti-CD3E (1-982) [scFv-VH-V-kappa anti-DLL3 (1-241) [VH (Homo sapiens IGHV4-59*01 G49>C (44) (96.9%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.7.12] (26-33.51-57.96-107) (1-118) -15-mer-tris(tetraglycyl-seryl) linker (119-133) -V-KAPPA (Homo sapiens IGKV3-20*01 (91.7%) -IGKJ2*01 Q120>C (234) (90.9%)) CDR-IMGT [7.3.9] (160-166.184-186.223-231) (134-241)] -6-mer-seryl-tetraglycyl-seryl linker (242-247) -scFv-VH-V-lambda anti-CD3E (248-496) [VH (Mus musculus IGHV10-1*02 (91.9%) -(IGHD) -IGHJ3*01 (86.7%)/Homo sapiens IGHV3-73*01 (87.0%) -(IGHD) -IGHJ5*01 (100%)) CDR-IMGT [8.10.16] (273-280.298-307.346-361) (248-372)-15-mer-tris(tetraglycyl-seryl) linker (373-387) -V-LAMBDA (Homo sapiens IGLV7-43*01 (85.1%) -IGLJ3*02 (100%)) CDR-IMGT [9.3.9] (413-421.439-441.478-486) (388-496)] -4-mer-tetraglycyl linker (497-500) - scFc (h-CH2-CH3)-(h-CH2-CH3) (501-982) [Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 (hinge 6-15 (501-510), CH2 R83>C (572), N84.4>G (577), V85>C (582) (511-620), CH3 E12 (636), M14 (638) (621-725), CHS>del) (501-725) -30-mer-hexakis(tetraglycyl-seryl) linker (726-755) -Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 (hinge 6-15 (756-765), CH2 R83>C (827), N84.4>G (832), V85>C (837) (766-875), CH3 E12 (891), M14 (893) (876-980), CHS (981-982)) (756-982)]], produced in Chinese hamster ovary (CHO) cells, non-glycosylated

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