Тебентафусп

USAN (наименование, принятое к употреблению в США)

DB15283

Прочие противоопухолевые препараты

N (не классифицировано FDA)

1874157-95-5

immunoglobulin scFv, anti-[Homo sapiens CD3E (CD3 epsilon)] fused to T cell receptor beta (TRB) chain; dimer with T cell receptor alpha (TRA) chain, anti-[gp100_280-288-HLA-A2, YLEPGPVTA peptide 280-288 of PMEL (premelanosome protein, gp100, melanocyte differentiation protein) presented by MH1 HLA-A*0201), humanized monoclonal antibody single chain fused to Homo sapiens T cell receptor alpha-beta soluble; bispecific;
IG-scFv-TR-BETA (1-500) [humanized V-KAPPA (Homo sapiens IGKV3-33*01 (87.2%) -IGKJ1*01 (100%)) [6.3.9] (1-107) -24-mer tetra(tetraglycyl-seryl)-triglycylseryl linker (108-131) -humanized VH (Homo sapiens IGHV3-66*01 (76.8%) -(IGHD) -IGHJ4*01 (93.3%)) [8.8.15] (132-253) -5-mer tetraglycyl-seryl linker (254-258) -Homo sapiens V-BETA (TRBV19*01 (95.7%) -(TRBD) -TRBJ2-7 (100%)) [5.6.11] (259-370) -Homo sapiens C-BETA (TRBC2*01 EX1 1.7-125, EX2 1 (97.7%) S79>C (427), C85.1>A (445), N97>D (459)) (371-500)], disulfide (427-157') with TR-ALPHA chain (1'-195') [Homo sapiens V-ALPHA (TRAV17*01 (98.9%) -TRAJ29*01 (100%)) [5.7.9] (1'-109') -C-ALPHA (TRAC*01 EX1 1.3-119, N1.2>K (113), T84>C (157) (97.6%)) (110'-195')]

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