Зенокутузумаб

Rec. INN (наименование, зарегистрированное ВОЗ)

DB15559

1969309-56-5

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3) and Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody, bispecific;
gamma1 heavy chain anti-ERBB3 (1-453) [Homo sapiens VH (IGHV1-2*02 (100.00%) -(IGHD) -IGHJ4*01) [8.8.17] (1-124) -Homo sapiens IGHG1*03, G1m3, nG1m1 (CH1 R120 (221) (125-222), hinge (223-237), CH2 (238-347), CH3 L7>K (358), E12 (363), M14 (365), T22>K (373) (348-452), CHS K>del (453)) (125-453)], (227-214')-disulfide with kappa light chain (1’-214’) [Homo sapiens V-KAPPA (IGKV1-39*01 (100.00%) -IGKJ1*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 A45.1 (153), V101 (191) (108'-214')];
gamma1 heavy chain anti-ERBB2 (1-450) [humanized VH (Homo sapiens IGHV1-46*01 (83.70%) -(IGHD) -IGHJ4*01) [8.8.14] (1-121) -Homo sapiens IGHG1*03, G1m3, nG1m1 (CH1 R120 (218) (122-219), hinge (220-234), CH2 (235-344), CH3 L7>D (355), E12 (360), M14 (362), L24>E (372) (345-449), CHS K>del (450)) (122-450)] (224-214')-disulfide with kappa light chain (1’-214’) [Homo sapiens V-KAPPA (IGKV1-39*01 (100.00%) -IGKJ1*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 A45.1 (153), V101 (191) (108'-214')];
dimer (233-230":236-233")-bisdisulfide

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