Датопотамаб дерукстекан

Rec. INN (наименование, зарегистрированное ВОЗ)

DB16410

2238831-60-0

immunoglobulin G1-kappa, anti-[Homo sapiens TACSTD2 (tumorassociated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epithelial glycoprotein-1, EGP-1, trophoblast antigen-2, cell surface glycoprotein Trop-2, TROP2)], humanized monoclonal antibody conjugated to deruxtecan, comprising a linker and a camptothecin derivative;
gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV1- 3*01(79.6%) -(IGHD) -IGHJ4*01 (93.3%)) CDR-IMGT [8.8.14] (26-33.51- 58.97-110) (1-121) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 (235-344), CH3 E12 (360), M14 (362) (345-449), CHS (450-451)) (122-451)], (224-214')- disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (84.2%) -IGKJ2*01 (100%)) CDR-IMGT [6.3.9] (27- 32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')];
dimer (230-230'':233-233'')-bisdisulfide; produced in Chinese hamster ovary (CHO) cells, glycoform alfa, conjugated, on an average of 4 cysteinyl, to deruxtecan, comprising a linker and a camptothecin derivative

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