Гемтузумаб озогамицин
Gemtuzumab ozogamicinМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB00056
АТХ
Код МКБ 10
Категория при беременности по FDA
D (риск доказан)
CAS
220578-59-6
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens CD33 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67)], humanized monoclonal antibody conjugated to N-acetyl-gamma calicheamicin;
gamma4 heavy chain (1-443) [humanized VH (Homo sapiens IGHV1-3*01 (72.90%) -(IGHD) -IGHJ5*01) [8.8.9] (1-116)), IGHG4*01 (CH1 (117-214), hinge S10>P (224) (215-226), CH2 (227-336), CH3 (337-441), CHS (442- 443)) (117-443)], (130-218')-disulfide with kappa light chain (1'-218') [humanized V-KAPPA (Homo sapiens IGKV1- 5*01 (81.90%) -IGKJ1*01) [10.3.9] (1'-111') -Homo sapiens IGKC*01, Km3 (112'-218')]; dimer (232-232":235-235")- bisdisulfide; conjugated, on an average of 2 or 3 lysyl (0-6), to N-acetyl-S'-des(methylsulfanyl)-S'-(4-hydrazinyl-2- methyl-4-oxobutan-2-yl)calicheamicin γ1 via a bifunctional 4-(4-acetylphenoxy)butanoyle (AcBut) linker
gamma4 heavy chain (1-443) [humanized VH (Homo sapiens IGHV1-3*01 (72.90%) -(IGHD) -IGHJ5*01) [8.8.9] (1-116)), IGHG4*01 (CH1 (117-214), hinge S10>P (224) (215-226), CH2 (227-336), CH3 (337-441), CHS (442- 443)) (117-443)], (130-218')-disulfide with kappa light chain (1'-218') [humanized V-KAPPA (Homo sapiens IGKV1- 5*01 (81.90%) -IGKJ1*01) [10.3.9] (1'-111') -Homo sapiens IGKC*01, Km3 (112'-218')]; dimer (232-232":235-235")- bisdisulfide; conjugated, on an average of 2 or 3 lysyl (0-6), to N-acetyl-S'-des(methylsulfanyl)-S'-(4-hydrazinyl-2- methyl-4-oxobutan-2-yl)calicheamicin γ1 via a bifunctional 4-(4-acetylphenoxy)butanoyle (AcBut) linker
Структура
Иностранные названия
- Gemtuzumabum ozogamicinum (латинское)
- Gemtuzumab ozogamicin (английское)
- Gemtuzumab ozogamicin (немецкое)
- Gemtuzumab ozogamicine (французское)
- Gemtuzumab ozogamicina (испанское)
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