Мирветуксимаб соравтансин

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB12489

N (не классифицировано FDA)

1453084-37-1

immunoglobulin G1-kappa, anti-[Homo sapiens FOLR1 (folate receptor 1, folate receptor alpha, FR-alpha, adult folate-binding protein, FBP, ovarian tumor-associated antigen MOv18)], chimeric monoclonal antibody conjugated to maytansinoid DM4;
gamma1 heavy chain (1-447) [Mus musculus VH (IGHV1- 37*01 -(IGHD)-IGHJ4*01) [8.8.11] (1-118) -Homo sapiens IGHG1*01, G1m17,1 (CH1 (119-216), hinge (217-231), CH2 (232-341), CH3 (342-446), CHS K2>del (447)) (119- 447)], (221-218')-disulfide with kappa light chain (1'-218') [Mus musculus V-KAPPA (IGKV3-9*01 -IGKJ2*01) [10.3.9] (1'-111') -Homo sapiens IGKC*01, Km3 (112'-218')]; dimer (227-227'':230-230'')-bisdisulfide;conjugated, on an average of 3 or 4 lysyl, to maytansinoid DM4 [N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine] via the reducible sulfo-SPDB linker [N-succinimidyl 4-(2-pyridyldithio)-2-sulfobutanoate]

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