Сацитузумаб тирумотекан

Rec. INN (наименование, зарегистрированное ВОЗ)

2768350-77-0

immunoglobulin G1-kappa, anti-[Homo sapiens TACSTD2 (tumor-associated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epithelial glycoprotein-1, EGP-1, trophoblast antigen-2, cell surface glycoprotein Trop-2, TROP2)], humanized monoclonal antibody; conjugated to the topoisomerase I inhibitor tirumotecan;
gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV7-4-1*02 (85.70%) -(IGHD)-IGHJ4*01 (86.7) T122>S (115), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*03, G1m3, nG1m1CH1 R120, CH3 E12, M14 (CH1 R120 (218) (122-219), hinge (220-234), CH2 (235-344), CH3 E12 (360), M14 (362) (345-449), CHS (450-451)) (122-451)], (224-214')- disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-9*01 (82.2%) -IGKJ4*01 (91.7%) G120>A (100), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01, Km3, A45.1 (153'), V101 (191') (108'-214')]; dimer (230-230":233-233")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa; substituted at the sulfur atoms of eight l-cysteinyl residues with 5-(6-{[(1-{(34S)-38-amino-34-[(4-{[({[(4S)-4-ethyl-11-{2-[N-(propan-2-yl)methanesulfonamido]ethyl}-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]oxy}carbonyl)oxy]methyl}phenyl)carbamoyl]-28,32-dioxo-3,6,9,12,15,18,21,24,30-nonaoxa-27,33-diazaoctatriacontan-1-yl}-1H-1,2,3-triazol-4-yl)methyl]amino}-6-oxohex-1-yn-1-yl)pyrimidin-2-yl (tirumotecan) groups

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