Сибепренлимаб
SibeprenlimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2382896-07-1
Химическое название
immunoglobulin G2-kappa, anti-[Homo sapiens TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256)], humanized monoclonal antibody;
gamma2 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-46*01 (85.7%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Homo sapiens IGHG2*01 (100%), G2m.. CH2 V45.1 (CH1 (121-218), hinge 1-12 (219-230), CH2 V45.1 (281) (231-339), CH3 (340-444), CHS (445-446)) (121-446)], (134-218')-disulfide with kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV3-15*01 (85.9%) -IGKJ4*01 (100%)) CDR-IMGT [10.3.9] (27-36.54-56.93-101) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (222-222'':223-223'':226-226”:229-229”)-tetrakisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 derived cell line, glycoform alfa
gamma2 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-46*01 (85.7%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Homo sapiens IGHG2*01 (100%), G2m.. CH2 V45.1 (CH1 (121-218), hinge 1-12 (219-230), CH2 V45.1 (281) (231-339), CH3 (340-444), CHS (445-446)) (121-446)], (134-218')-disulfide with kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV3-15*01 (85.9%) -IGKJ4*01 (100%)) CDR-IMGT [10.3.9] (27-36.54-56.93-101) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (222-222'':223-223'':226-226”:229-229”)-tetrakisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 derived cell line, glycoform alfa
Структура
Иностранные названия
- Sibeprenlimabum (латинское)
- Sibeprenlimab (английское)
- Sibeprenlimab (немецкое)
- Sibéprenlimab (французское)
- Sibeprenlimab (испанское)
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